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OncoNano has pioneered an ultra pH-sensitive, polymeric micelle platform technology to selectively deliver high-value small molecule and biologic payloads to a wide range of tumor types for use across the continuum of cancer care: Diagnosis, Staging, Surgery and Treatment. The mechanism of action utilizes the low pH tumor microenvironment (TME; Warburg) as a universal biomarker for solid cancers. An imaging program (ONM-100) is in Ph 2 trials for intraoperative tumor resection, and in Ph 1 trials was well-tolerated, identified 100% of tumors found by standard of care (SOC), and occult disease undetected by SOC in 30% of the patients. The results have validated use of the micelles for therapeutic applications that are in preclinical phase: (i) ON-BOARD™ to selectively deliver micelle-encapsulated small molecules, antibody fragments, and cytokines (e.g. IL-2) to the TME to improve therapeutic indexes, and (ii) OMNI™ for antigen-containing micelles that activate T-cell immune response.
![](/sites/default/files/hubb_images/2996/attachments/%2520-%2520f1_ONCONANO_20MEDICINE_2C_20INC__ab11b7d0.jpg)
Company Type:
Privately Funded Company
Company Website:
Company HQ State:
Texas
Company HQ Country:
United States
Year Founded:
2014
Main Therapeutic Focus:
Oncology
Lead Product in Development:
Mulitple therapeutic candidates being led by real-time imaging agent for surgercial resection.
Development Phase of Primary Product:
Phase II
Number Of Unlicensed Products (For Which You Are Seeking Partners):
2-3
Speaker
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