“None of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world’s most dangerous bacteria,” the World Health Organization (WHO) announced when releasing a new report on the antibiotic pipeline. Here’s what you need to know.
The WHO’s fourth annual report,Antibacterial Pipeline Report, looks at the pipeline for antibiotics to address antimicrobial resistance, or AMR. In addition to clinical and preclinical antibiotics, this year’s report looks at non-traditional products like monoclonal antibodies, too.
“Almost all the new antibiotics that have been brought to market in recent decades are variations of antibiotic drugs classes that had been discovered by the 1980s,” said WHO. For these drugs, “resistance mechanisms are well established and rapid emergence of resistance is foreseen.”
A key obstacle to development—cited both in the report and by BIO—is the lack of mechanisms to ensure drug developers can recoup the cost of developing these kinds of drugs.
The WHO report notes the benefits of the AMR Action Fund,launched last year by 20+ biopharmaceutical companies (including many BIO members) pledging $1 billion to support the pipeline and bring 2-4 new antibiotics to the market by 2030. WHO says the fund can help encourage development, but cannot guarantee manufacturers will sell enough of an approved drug to make investment sustainable.
That’s why we need policy solutions, continues the report—like the PASTEUR Act, which would provide biopharma companies with a fixed annual payment from the government for ensuring access to antibiotics, regardless of how many are sold. (Read what BIO’s Dr. Michelle McMurry-Heath said about it.)
Read: AMR is a “major looming threat to global health systems,” causing between 50K-162K deaths in the United States each year, says Sally Greenberg, Executive Director of the National Consumers League (NCL). Read the whole thing.
Listen: “Bugs always win,” said Dr. Evan Loh, CEO of Paratek, which commercialized NUZYRA, a new antibiotic to treat pneumonia. Listen to the conversation on the I AM BIO Podcast.
More Health Care News:
POLITICO: The most promising coronavirus vaccine you’ve never heard of
“Novavax’ rise comes as pressure to increase the supply of COVID-19 vaccines is growing amid concerns that unequal access globally will extend the pandemic.”