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How many patents has the PTO issued covering gene sequences?
The PTO has issued far fewer patents encompassing gene sequences than it has patents on inventions in the fields of electronics, telecommunications, medical devices and advanced materials. As of the end of 2001, the PTO had issued over 6,500 patents covering gene and open reading frame sequences (DNA sequences that code for proteins). Of these, over 1,300 patents were for human genes or open reading frames. To date more than 20,000 applications for genes, DNA fragments, SNPs and so forth have been submitted for review.
Major holders of gene-based patents as of year-end 1999 were
| U.S. Government | 388 patents |
| Incyte Pharmaceuticals | 356 patents |
| University of California | 265 patents |
| SmithKline Beecham | 197 patents |
| Genentech | 175 patents |
| Eli Lilly | 145 patents |
| Novo Nordisk | 142 patents |
| Chiron | 129 patents |
| American Home Products | 117 patents |
| Isis Pharmaceuticals | 108 patents |
| Massachusetts General Hospital | 108 patents |
| Human Genome Sciences | 104 patents |
| University of Texas | 103 patents |
| Institut Pasteur | 101 patents |
U.S. inventors predominate as recipients of U.S. patents in genetic engineering. Other countries with a strong patent showing in the field are Japan, the United Kingdom and Germany.

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