this page only  
Join BIO   |   Member Directory   |    Contact BIO    
Biotechnology Industry Organization

Home
About BIO
Conferences & Events
Past BIO Events
Industry Calendar
State/Int'l Calendar
Members.BIO.org
BIO News Online
BIO Bulletins
Suggestion Box
Membership Directory
BIO Videos
News & Media
BIO Blogs & Podcasts
National Issues
Health
Food & Agriculture
Industrial & Environmental
Bioethics
Intellectual Property
Regulatory
Tax & Financial
State & Local Issues
State by State Initiatives
Letters, Testimony & Comments
Speeches & Publications
Industry At-a-Glance
Business & Finance
BIO News


Sunday, November 22, 2009

Playing the game, for better...

Click here for a printer-friendly page Printer Friendly

An interview with Nasdaq vice chairman Alfred R. Berkeley III
from Biotechnology Investors' Forum – Worldwide – Issue 2 2002
www.biotechnology-investor.com

Alfred R. Berkeley III
Alfred R. Berkeley III

With biotechnology and many other industry sectors in sharp decline on stock markets worldwide, Charles Craig, chairman of the editorial board for Biotechnology Investor's Forum, sought out Alfred R. Berkeley III for advice in making sense of the perturbations. This interview was conducted August 28, 2002 – the day Nasdaq received approval from the Securities and Exchange Commission (SEC) to implement major changes in the way stock trades are executed.

Having been president of Nasdaq Stock Market Inc. since 1996, Berkeley was appointed vice chairman on July 27, 2000. Before joining the stock exchange he was managing director and senior banker in the Corporate Finance Department of Alex, Brown & Sons. Berkeley served as a US Air Force captain from 1968 to 1972. He received an MBA from the Wharton School at the University of Pennsylvania and a bachelor of arts from the University of Virginia. He is also a trustee of John's Hopkins University and the Nature Consevancy.

Biotechnology Investor's Forum (BIF): What can Nasdaq do to address volatility?

Berkeley: There are two elements to the volatility. One is the flow of funds in and out of the biotech industry, and there's not a thing we can do about that other than help publicize the benefits of long-term biotech investing.

The second, smaller part of volatility is that which occurs in the market itself, and we're doing a lot about that. Specifically over the last three years, we have invested in rewriting all the software in Nasdaq, and that will be introduced no later than October 12. We received approval from the Securities and Exchange Commission this morning.

What we are doing is offering many more choices to investors in the way they use the market. We're going to give them all four major market models from around the world. They'll continue to be able to use our dealer structure. Nasdaq is structured like the currency markets – not like the traditional exchanges. We have multiple competing dealers, just as the currency markets and the international bond markets do, and that results in enormous liquidity.

"You will continue to see great interest in drug
candidates that look promising because, after all,
biotech is dealing with issues closest to our
hearts, which is our health"

We're offering the ability to execute electronically against any offering you see in the market. This is what the Electronic Communication Networks have been doing. We're offering you the ability to leave with Nasdaq a limit order that you would like displayed to the world; that's called a limit order book. We have introduced an electronic auction that says if you would like your stock auctioned off to the highest bidder, you can do that through Nasdaq.

These are very powerful additions to our technology. What this means is we're going to attract many more orders to the market. Orders that have been kept on the desks of the different brokerage firms will have a place in the center of the market to be seen and to be traded. We think this will produce even more liquidity and will dampen volatility.

BIF: When do you foresee a turnaround in the capital markets in general and in the biotech markets specifically?

Berkeley: I don't have any idea. When I was a lot younger and I was a lot smarter, I might have answered that glibly. But I think it's very difficult to guess the somewhat random movement of the market. Underlying any market turnaround is some positive indication that the economy is strengthening. The obvious question concerning people now is whether we're going to have a double- bottom recession. Until that is sorted out, you're not going to have a major move in the economy. You're not going to have a major move in the market. And you're not going to have a major move in biotech. In the long run, creating value in biotech stocks means creating drugs that work.

BIF: Will we ever see on Nasdaq the heady days for biotech stocks we saw in 2000 before the current decline began?

Berkeley: Yes. Human beings deal cyclically with the market. The biotech industry itself has had probably four cycles of boom followed by inattention and no interest since the late 1970s.

The cyclical movement depends on what's going on in the speculative character of the general market and what's going on in terms of new product introductions from the industry itself.

The real problem for the biotech industry is long development cycles, with so few products that turn out to be effective in human trials. You will continue to see great interest in drug candidates that look promising because, after all, biotech is dealing with issues closest to our hearts, which is our health. As time goes by and more products get to patients, the industry will develop a more substantial base. But right now you have a handful of companies that are proven and can sustain themselves when the speculative enthusiasm goes out of the market, which is the case now.

BIF: When will the initial public offering (IPO) market reopen for biotech stocks?

Berkeley: Right now you can't get institutional investors – who really are the key to the IPO market – to accept many deals at all. IPOs are priced by investment banks on an initial transaction. Institutional investors are saying with their wallets and their feet that they want to buy products that are priced by the market. They are taking advantage of the pessimism that exists in the market generally, to enjoy what is called a buyer's market, which is in contrast to the seller's market we had during the speculative bubble.

BIF: In 2000, one reason biotech IPOs attracted so much attention was completion of the human genome sequence. Will it take another monumental scientific milestone to renew enthusiasm? If so, what would it be?

Berkeley: It will take scientific milestones, but I don't think you will have a blockbuster milestone like the human genome sequencing. What people want next is pragmatism, which always follows pessimism. When you're in a pessimistic phase as we are now, you don't go right back to euphoria. You don't go from cynical, pessimistic hoarding of cash to euphoric buying of stocks. You go through a couple of psychological stages.

"Biotech companies showing good results in clinical phases of development, and introducing and marketing drugs, will do much better than biotech companies making promises"

The next stage is a pragmatic stage where people say, 'Show me the results.' Biotech companies showing good results in clinical phases of development, and introducing and marketing drugs, will do much better than biotech companies making promises.

BIF: Are biotech stocks still overvalued even at these depressed prices?

Berkeley: I don't know; it's difficult to say what the market is worth. There's a difference between the price at which a stock trades and the value of the company. That's the fundamental difference between the way speculators look at things and the way investors look at things.

Investors look at the true cash value of the company: 'When will I get cash out of this and how much cash will I get?' Whereas speculators are saying, 'What will someone else pay for this piece of paper?'

My guess is that some companies are undervalued, but most are not. We're going to see this pragmatic phase where people say, 'Show me real results.' Companies producing results will attract investment capital from those that are not. Companies try hard to sound like they have results, but some haven't proved it yet. When we go into a pragmatic phase of the market, people want proof.

BIF: When the market enters the next growth period, many experts say it will rise in a flatter fashion compared with the spikes we've seen recently.

Berkeley: That's absolutely true because of this pragmatism I'm talking about. The spike two years ago was the culminating stage of a speculative cycle. It wasn't the initial stage coming out of a bust. Things rise very slowly in recoveries and they only get ebullient and spiky when people forget the lessons of the previous crash.

BIF: What are the major factors affecting market cycles?

Berkeley: There's no magic to it. You have the emotional side of things and the rational side. Right now the emotional side is dominant because so many people have lost so much money; they're looking for other things to do with their money besides putting it at risk again. When you have a combination of a bad economy and a bad psychology, you have bear markets.

When you get a good economy, you don't necessarily have speculative enthusiasm, psychological enthusiasm, or emotional enthusiasm. It takes time for people to get to the point where you have both a good economy and optimistic emotions that cause people to take a chance on equities. After all, equities are all about the future. People have to feel the future is going to continue to be good, and people don't feel that way right now.

BIF: Will a resurgence of confidence in biotech stocks come from events within the biotech sector or from within the general economy?

Berkeley: For biotech to benefit, it is going to take both. What your readers need to understand is whether they are speculators, gamblers, or investors.

There are always three games going on in the market. According to game theory, there are games of chance, games of skill and games of strategy. Nobody talks like that; they talk about gambling, speculating and investing. And it's not polite to talk about gambling and speculating, so people use the language of investing, even though their behavior is that of a speculator or a gambler.

How do you tell which one you are? If you are playing a game of strategy and you are an investor, you're looking at basic supply and demand for a good or a service. In the case of a biotech company you might be looking for the basic supply and demand of a cure to a terrible disease. The supply is dictated by our regulated clinical trial system. The biotech company has to get through the regulators and then supply a product that is proven to work. Even if it does that, the company has to match demand with other elements. It's not sufficient just to have a product. The company must have a distribution system, must price the drug right, and must market it right. The company must have all the things that go into building a business. Investors look at all that, and they look at the strategies of the management team. They look at the capabilities of the management team. And, by the way, their holding periods are roughly coincident with the time it takes to work those strategies out. Investors are holding their shares of stock in a management team's efforts for years because that is how long it takes to work strategies out.

The next group, people playing a game of skill, are speculators. They are not looking at the supply and demand for the product. They are looking at what the crowd is going to do with the stock. They are speculating that more people will buy this stock than sell it. They may not even know the company's products. This is where stocks get priced differently from the value of the underlying cash flows.

"We have developed a national hunger for the combination of news and sports about finance. We want the urgency of news and we want the conflict and drama of sports"

Speculators typically hold stocks for months or quarters. They try either to pile on when the crowd changes direction (on the upside or the downside) or they try to anticipate the crowd's movement, which is a very risky game. The speculators' game is totally different in structure from the game investors play. The interesting aspect of speculators is that they dominate the action in the market. Many more transactions are executed by people trying to guess what the crowd is going to do than by people who buy and hold. That is almost common sense, because people who buy and hold are not trading.

Speculators are in there trading. They are creating Professor Burton G. Malkiel's A Random Walk Down Wall Street. And guess what happens? The gamblers come in and play that randomness. Gamblers know that any given morning there is a 50-percent chance that any given stock is going to go up or down. They try to figure out, using hedging strategies and options, how to play the randomness of the market. They are called day traders. They hold for minutes and hours.

The complexity here is that people can be investors with one part of their portfolios, speculators with another, gamblers with another. But what often happens – because it is not popular to talk about speculating – when people go to a cocktail party, they do not say, "I had a great speculation today." They don't say they had a great gamble today. They say they invested in such and such. Well, if they invested this morning and sold at lunchtime, they are probably gamblers, even though they are calling themselves speculators, or more likely calling themselves investors.

It is important for people to know which game they are playing. The questions you are asking me about the future of the biotech industry in the market do not depend on investment answers of supply and demand. The market is reflecting speculation.

Look at the way we amplify voice in this country. I live in Maryland and we have a state lottery. The State of Maryland has an advertising tag line that says, ‘You've got to play to win.' The state is telling my children they should gamble. And the state implies that if they are not gamblers, they are losers. It's terrible public policy. Many brokerage firms stress their low costs to get people into day trading and online investing. I suggest that is the amplification of gambling in our economy.

Then look at speculating. Every morning I get up and click on the television for the financial news. I just told you that was Malkiel's A Random Walk Down Wall Street. But I love it, and millions of people love it. We want our data fix of what's moving in the market.

If I said to you the cumulus clouds went across the sky from right to left over my house this morning, you would yawn and say, ‘Who cares?' If I said, ‘My god, IBM was up and General Motors (GM) was down,' somehow that conveys meaning and importance and you want to know more. But what IBM and GM do day-to-day is just as random as the movement of the clouds in the short term.

"If you want to be a long-term investor, you must invest in the quality of the management team because product life cycles are shorter than your investment cycle"

We have developed a national hunger for the combination of news and sports about finance. We want the urgency of news and we want the conflict and drama of sports. The television industry has given it to us. It is the cheapest possible television model – a couple of hosts responding to the ticker tape and inviting guests to comment. You can't get a cheaper television production model: one room, three cameras, two hosts, guests and a ticker tape. And we love it. The commentators do not respond to a consistent theme that may provide investment insights about the supply and demand for semiconductors, pills or automobiles. They respond to whatever is randomly moving up and down. They talk about the big gainers of the day, the big losers, the high-volume stocks, the low-volume stocks, and how the indices are doing. They are documenting the elements of the random walk in excruciating detail, and I and millions of others are glued to it. It is all about the random movement of stocks. We are amplifying the voices of speculation.

There are almost no voices amplifying the hard, difficult task of finding good investments. Mainly because in a culture that loves fast movement, it is really boring to talk about investments. I had a wonderful guy, a true investor, tell me he bought some Intel in 1975 and still owned it. Well, where is the drama? Where is the urgency? Where is the excitement? There is no television market for this. There is no amplification of voice. Yet he is actually the guy who has more money than anybody else. He has done extremely well by understanding the long buy; holding and playing the long-term growth of the basic components of the information age.

BIF: Is it possible to be a long-term investor today in biotech?

Berkeley: You have to pick one side of the game or the other. If you want to be a long-term investor, you must invest in the quality of the management team because product life cycles are shorter than your investment cycle. Said another way, you need to invest in management teams of companies that have a portfolio of products because they can adjust, regardless of the specific life cycle of their products. However, a particular problem of the biotech industry, including the pharmaceutical industry is this: it is one of the few industries in the world, including the United States, that has government working against it. This is a very difficult situation.

You have state governments and the US government trying to reduce the ability of biotech and pharma companies to earn a profit on their inventions by imposing price controls and challenging patent protections. There are extraordinarily well-managed companies out there fighting not only the normal competition that comes into these industries, but also the long odds of successful drug discovery and the short-term nature of government interest, which leads to price controls.

It is possible for people to be long-term investors in biotech and in pharma. But they should put their money in companies with management teams that have the ability to make changes because the business they are investing in is fluid and requires sophisticated people to manage it.

BIF: Has consolidation of financial institutions affected the capital markets?

Berkeley: Yes it has – on several levels. First, at the level of the large mutual funds. The very large funds account for a huge rule (much more than the 80/20) of the business in the market today. And there is continuing consolidation within these large fund companies by managers; you get more centralization of policy and you get a move to larger and larger cap stocks. I talked with a venture capitalist in Menlo Park. She said the supply chain for new companies is broken. Her venture capital fund was having trouble finding analysts to cover their companies; brokerage firms were not investing in research in the middle of a recession.

She is absolutely right; we have a bottleneck. We probably have 3,000 companies targeted by analysts out of 18,000 public companies in the United States. Wall Street has become a bottleneck for investors seeking critical and serious information on companies. Some of the current academic work on this issue says companies should purchase research from investment banks or from sources other than investment banks, such as trade associations that offer research on a contractual basis. Some new mechanism must emerge to get the word out about companies, and it is probably a growth in the investor relations business.

BIF: When you talk about trade associations, are you referring to the Biotechnology Industry Organization (BIO)?

Berkeley: BIO would be one. Or if your readers go to the Nasdaq website, www.nasdaq.com/xbrl/, they will see a demonstration of the extensible business reporting language we established with the semiconductor industry. We have 20 semiconductor companies. With a click of the mouse an investor can find relevant information in comparative formats from the semiconductor companies.

BIF: Let's move on to another topic of great concern, corporate fraud. Who can protect investors from corporate crooks?

Berkeley: There are a few crooks in any business. The vast majority of executives in companies in the US public markets are hard working and honest. We have had some egregious excesses. But those excesses can be laid at the door steps of greedy managers, and perhaps some greedy accountants and lawyers.

But I would suggest – and this is radical thinking – that the Financial Accounting Standards Board (FASB) is largely responsible for these problems by putting out confusing financial guidelines, by having pages of exceptions and by going for a performanceoriented rather than a principlesbased approach to accounting. And a major reason for this is FASB's accommodation of highly technical interpretation- of-the-day rules combined with the plaintiff's bar in the United States. These two factors have driven people to create a highly technical approach to what's right and what's wrong. The pendulum, however, is swinging back. People are saying, ‘Wait a minute. Even though each of these off balance sheet vehicles is in its own right legal, we are missing the basic principle of reporting fairly.'

We are going back toward a common sense principled approach: Does this financial statement represent accurately to investors what is going on? What is required in this country is a thorough examination of how FASB got off track, not how the accounting firms or the companies did, although they clearly had a role in it. We also need to think through the unintended consequences of an entrepreneurial plantiff's bar.

BIF: Let's talk about Nasdaq's global strategy. How is it progressing?

"We think the way to grow in Europe is to focus on smaller markets and negotiate alliances and partnerships with those markets to increase liquidity"

Berkeley: We continue to think that if investors around the world have 1,000, 10,000 or 100,000 shares in Amgen, they will be better served if there's a global market in which everybody sees everybody else's interests. That's a simple concept. Yet the implementation of it is very difficult because of sovereignty and because of entrenched financial interests. We want to continue to work toward that goal, but we were getting nowhere in Japan and we had to cut our losses for a while. We would like to come back into Japan at the right time, but we must figure out a better way to do it because we didn't do it right the first time.

BIF: What about Nasdaq efforts in Europe?

Berkeley: We are progressing in Europe. We think the way to grow in Europe is to focus on smaller markets and negotiate alliances and partnerships with those markets to increase liquidity. In a recession, like we are in now, there is almost no cross-border trading, so a pan- European market doesn't work.

We have deals with a German market and we have a license in Brussels to operate throughout Europe, which would be pan- European. We also have a separate license to operate in the UK, which we're not doing. We're picking that up through the Brussels operation.

BIF: Is Nasdaq operating in India?

Berkeley: We have an office in India, as we do in San Paolo, Brazil. We are looking for listings for the US market there and the European markets.

BIF: How has the decline in stock prices on Nasdaq affected your ability to compete with other stock exchanges in the United States and around the world?

Berkeley: In terms of trading in the secondary markets – stocks already issued – our trading volume and everybody else's trading volume is off a little. But the strength of our liquidity engine, and in particular the technology that we had approved by the SEC this morning, should give us the strongest market in the world. People who are students of markets will recognize this is extraordinarily powerful technology.

That being said, there also is the primary market, which includes IPOs. There are not many in the biotech or computer technology sectors. There are not many first-time consumeroriented companies either, or financial industry sector IPOs. Most of the IPOs are spin-outs of large companies, and most are going to the New York Stock Exchange where the parent companies are listed. So, we are not competing as effectively for IPOs because there aren't as many IPOs that are truly new companies.

BIF: Would you discuss Nasdaq's delisting rules? With all the volatility, even good companies may find themselves in trouble.

Berkeley: Unfortunately the delisting rules are a little too clear. For example, they say a company is to be delisted when it's share price drops below $1 for 30 days. There are some very good companies that have gotten caught up in this down market and have seen their share prices go below $1. We had implemented a moratorium on the 30-day rule, but that has since been suspended and we have returned to our normal rules. I wish we were not quite so dogmatic, but the rules have the force of law and we do not have much room to interpret them. We have probably thrown some good companies off the market that should not have been delisted, but usually the companies have the option of reverse splitting their stock, and if they do, they often stay above a dollar.

contact us | terms of use | privacy policy
© 2009 | Biotechnology Industry Organization | 1201 Maryland Ave., SW, Ste. 900 | Washington, D.C. 20024